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Unveiling Hidden Neural Codes: SIMPL – A Scalable and Fast Approach for Optimizing Latent Variables and Tuning Curves in Neural Population Data

Dr. Rishabh Pathak
This research paper presents SIMPL (Scalable Iterative Maximization of Population-coded Latents), a novel, computationally efficient algorithm designed to refine the estimation of latent variables and tuning curves from neural population activity. Latent variables in neural data represent essential low-dimensional quantities encoding behavioral or cognitive states, which neuroscientists seek to identify to understand brain computations better. Background and Motivation Traditional approaches commonly assume the observed behavioral variable as the latent neural code. However, this assumption can lead to inaccuracies because neural activity sometimes encodes internal cognitive states differing subtly from observable behavior (e.g., anticipation, mental simulation). Existing latent variable models face challenges such as high computational cost, poor scalability to large datasets, limited expressiveness of tuning models, or difficulties interpreting complex neural network-based functio...
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Focal seizure with occipital onset

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Dr. Rishabh Pathak


 

Focal seizures with occipital onset originate in the occipital lobe, which is primarily responsible for visual processing.

1.      Ictal Patterns:

o    The EEG findings during focal seizures with occipital onset typically show diphasic sharp waves that may evolve into rhythmic activity. This rhythmic activity can become more pronounced over time, often encompassing bilateral posterior head regions while remaining localized to the occipital area.

2.     Clinical Manifestations:

o Patients experiencing occipital seizures may present with visual symptoms, such as visual hallucinations, flashes of light, or other visual distortions. These seizures can also lead to eye movements, such as eyelid flutter or upward gaze, which are common manifestations of occipital lobe involvement.

3.     EEG Characteristics:

o The ictal pattern in occipital seizures is characterized by phase reversals at the occipital electrodes, particularly at O1 and O2. The rhythmic activity may spread to adjacent regions but typically does not extend to frontal or central areas.

4.    Associated Conditions:

o  Focal seizures with occipital onset can be associated with various conditions, including structural lesions such as cortical dysplasia, tumors, or post-traumatic changes in the occipital lobe. In some cases, these seizures may occur in the context of idiopathic occipital lobe epilepsy.

5.     Diagnosis and Management:

o  Diagnosis often involves a combination of clinical history, EEG monitoring, and neuroimaging (such as MRI) to identify any underlying structural abnormalities. Management may include antiepileptic medications, and in cases where seizures are refractory to medical treatment, surgical options may be considered.

6.    Prognosis:

o  The prognosis for patients with occipital seizures can vary based on the underlying cause and the response to treatment. Some patients may achieve good seizure control with medication, while others may require more intensive interventions.

In summary, focal seizures with occipital onset are characterized by specific ictal patterns and clinical features related to visual disturbances. Understanding these seizures is essential for accurate diagnosis and effective management, particularly in the context of occipital lobe epilepsy.

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