This research paper presents SIMPL (Scalable Iterative Maximization of Population-coded Latents), a novel, computationally efficient algorithm designed to refine the estimation of latent variables and tuning curves from neural population activity. Latent variables in neural data represent essential low-dimensional quantities encoding behavioral or cognitive states, which neuroscientists seek to identify to understand brain computations better. Background and Motivation Traditional approaches commonly assume the observed behavioral variable as the latent neural code. However, this assumption can lead to inaccuracies because neural activity sometimes encodes internal cognitive states differing subtly from observable behavior (e.g., anticipation, mental simulation). Existing latent variable models face challenges such as high computational cost, poor scalability to large datasets, limited expressiveness of tuning models, or difficulties interpreting complex neural network-based functio...
Focal seizures with occipital onset originate in the occipital lobe, which is primarily responsible for visual processing. 1. Ictal Patterns : o The EEG findings during focal seizures with occipital onset typically show diphasic sharp waves that may evolve into rhythmic activity. This rhythmic activity can become more pronounced over time, often encompassing bilateral posterior head regions while remaining localized to the occipital area. 2. Clinical Manifestations : o Patients experiencing occipital seizures may present with visual symptoms, such as visual hallucinations, flashes of light, or other visual distortions. These seizures can also lead to eye movements, such as eyelid flutter or upward gaze, which are common manifestations of occipital lobe involvement. 3. EEG Characteristics : o The ictal pattern in occipital seizures is characterized by phase...