The authors propose
using vitamin C as an adjuvant therapy in conjunction with established methods
for treating malignant melanoma. It is suggested that vitamin C can change the
epigenetic pattern of melanoma cells, alter the disease's severity, inhibit DNMT
activity, increase the expression of connexin 43, cause apoptosis in melanoma
cell lines, make melanoma cells more sensitive, lower the levels of HIF-1 alpha
protein, reduce inflammatory cytokines, and lessen the spread of the cancer.
The effectiveness, safety, and mechanism of vitamin C in actual melanoma
patients should be tested through additional long-term experimental research
and clinical studies, according to the scientists. Additionally, based on
clinical evidence from many trials supporting its utility, they recommend
supplementing melanoma patients with Vitamin C and may pursue intravenous
dosing in the future.
Osman, H. O.,
Thomas, N. E., Udekwe, S., Habashy, S., Jafri, A., & Heindl, S. E. (2021).
Contribution of Vitamin C in the Treatment of Malignant Melanoma. Fortune
Journal of Health Sciences, 4(3), 383-393. https://doi.org/10.26502/fjhs.029
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