Sensitive of surface morphology with respect to Growth Ratio

Dr. Rishabh Pathak

The sensitivity of surface morphology with respect to the growth ratio between the cortex and subcortex is a critical aspect in understanding the mechanisms of cortical folding and brain development. Here are some key points regarding the sensitivity of surface morphology to the growth ratio:


1.     Secondary Folds Formation: The growth ratio between the cortex and subcortex is a key parameter controlling the formation of secondary folds in the cerebral cortex. Variations in the growth ratio can lead to changes in the complexity and distribution of cortical folds, influencing the overall surface morphology of the brain.


2.     Impact on Folding Patterns: The growth ratio influences the rate and extent of cortical growth, which in turn affects the folding patterns of the cortex. Variations in the growth ratio can result in alterations in the depth, frequency, and orientation of cortical folds, shaping the overall morphology of the brain surface.


3. Mechanotransduction Pathways: The growth ratio between the cortex and subcortex is linked to Mechanotransduction pathways that regulate cellular responses to mechanical stimuli. Changes in the growth ratio can modulate these pathways, leading to alterations in cell growth, proliferation, and tissue remodeling, which impact cortical folding patterns.


4.     Computational Modeling: Computational models can simulate the sensitivity of surface morphology to variations in the growth ratio by adjusting this parameter and observing the resulting changes in cortical folding patterns. These models provide insights into how the growth ratio influences the morphological features and structural organization of the cerebral cortex.


5.   Cellular Mechanisms: The growth ratio is closely tied to cellular mechanisms such as axon elongation, cell proliferation, and tissue growth, which collectively contribute to cortical development and folding. Understanding the interplay between the growth ratio and cellular processes is essential for unraveling the complexities of brain morphogenesis.


6.     Clinical Implications: Abnormalities in the growth ratio between cortical layers have been implicated in various neurodevelopmental disorders and brain pathologies. Investigating the sensitivity of surface morphology to the growth ratio can provide valuable insights into the underlying mechanisms of these conditions and potential therapeutic targets.


7.  Biological Significance: The growth ratio is a fundamental parameter that governs the dynamic changes in brain structure during development. It reflects the intricate balance between cortical and subcortical growth processes and their impact on cortical folding, highlighting the biological significance of the growth ratio in shaping brain morphology.


By exploring the sensitivity of surface morphology to the growth ratio, researchers can enhance their understanding of the mechanical and biological factors that drive cortical folding and brain development. This knowledge is essential for deciphering the complex interplay between growth processes, cellular mechanisms, and structural changes in the developing brain.

 

Having a strong interest in research, I began my work as a physiotherapist and went on to earn a master's degree in the field, specializing in neurology. I also finished a few post-graduation diplomas in between and with persistence. Research has always been a passion of mine, both for the advancement of my career and my personal life. A major factor in reaching my goals is education. Although my first bachelor's thesis was in the innovation area, I had been exposed to research work even in my informal school days. I always like working on creative initiatives and taking an interest in other people's experiences. The saying, "Healthy criticism is a way to learn more and more about your flaws to make them rectified," is true, in my opinion. In this way, we may hone our abilities and create a growth-oriented vision for both our personal and professional career pathways. I am thus constantly willing to learn and advance in my work. Additionally, I think that "it is in our hands to terminate our lives with a brand-new ending if we are unable to originate our lives with a brand-new start."

Comments

Post a Comment

Popular posts from this blog

Neural Circuits and Computation

Dr. Rishabh Pathak
Image
  Neural circuits and computation refer to the intricate networks of interconnected neurons in the brain that work together to process information and generate behaviors. Here is a brief explanation of neural circuits and computation: 1.  Neural Circuits : Neural circuits are pathways formed by interconnected neurons that communicate with each other through synapses. These circuits are responsible for processing sensory information, generating motor commands, and mediating cognitive functions. 2.   Computation in Neural Circuits : Neural circuits perform computations by integrating and processing incoming signals from sensory inputs or other neurons. This processing involves complex interactions between excitatory and inhibitory neurons, synaptic plasticity, and feedback mechanisms. 3.   Behavioral Relevance : Neural circuits play a crucial role in mediating specific behaviors by translating sensory inputs into motor outputs. Different circuits are specialized for various functions, su
Read more

How do NTN and Lmx1α influence the Notch signaling pathway during this differentiation process?

Dr. Rishabh Pathak
Image
  In the differentiation of human bone marrow mesenchymal stem cells (h-BMSCs) into dopaminergic neuron-like cells, NTN (Neurturin) and Lmx1α (LIM homeobox transcription factor 1 alpha) play a significant role in influencing the Notch signaling pathway. The study discussed in the PDF file investigated the impact of NTN and Lmx1α on the differentiation process and the associated changes in Notch-related gene expression. 1. Neurturin (NTN):    - Neurturin is a neurotrophic factor that belongs to the glial cell line-derived neurotrophic factor (GDNF) family. It has been shown to promote the survival and differentiation of dopaminergic neurons.    - In the study, h-BMSCs overexpressing NTN were induced to differentiate into dopaminergic neuron-like cells. The presence of NTN likely influenced the expression of Notch-related genes, leading to changes in the Notch signaling pathway during differentiation.   2. LIM homeobox transcription factor 1 alpha (Lmx1α):    - Lmx1α is a trans
Read more

Are there any potential side effects or limitations to consider when using Vitamin C as a treatment for malignant melanoma?

Dr. Rishabh Pathak
Image
  When using Vitamin C as a treatment for malignant melanoma, it is important to consider potential limitations and side effects. Some limitations include the lack of in vivo factors in in vitro studies, which may not fully represent biological interactions in real patients. Additionally, the studies mentioned in the review article were conducted in stimulating environments rather than in actual patients, which could affect the translation of results to clinical practice. As for side effects, while Vitamin C has shown promising anti-tumor effects in melanoma cells, further research is needed to fully understand its efficacy and safety in real patients. It is crucial to conduct more studies to investigate Vitamin C's role in transforming the genetic nature of melanoma and to evaluate its potential side effects when used as an adjuvant therapy. Osman, H. O., Thomas, N. E., Udekwe, S., Habashy, S., Jafri, A., & Heindl, S. E. (2021). Contribution of Vitamin C in the Treatment o
Read more