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Unveiling Hidden Neural Codes: SIMPL – A Scalable and Fast Approach for Optimizing Latent Variables and Tuning Curves in Neural Population Data

Dr. Rishabh Pathak
This research paper presents SIMPL (Scalable Iterative Maximization of Population-coded Latents), a novel, computationally efficient algorithm designed to refine the estimation of latent variables and tuning curves from neural population activity. Latent variables in neural data represent essential low-dimensional quantities encoding behavioral or cognitive states, which neuroscientists seek to identify to understand brain computations better. Background and Motivation Traditional approaches commonly assume the observed behavioral variable as the latent neural code. However, this assumption can lead to inaccuracies because neural activity sometimes encodes internal cognitive states differing subtly from observable behavior (e.g., anticipation, mental simulation). Existing latent variable models face challenges such as high computational cost, poor scalability to large datasets, limited expressiveness of tuning models, or difficulties interpreting complex neural network-based functio...
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Until gestational Week 18 the cortex forms its six layered structure

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Dr. Rishabh Pathak

Until gestational week 18, a significant period in brain development unfolds as the cortex forms its six-layered structure. Here is an explanation of the importance of gestational week 18 in the context of cortical layer formation:


1.  Six-Layered Cortex Development: Between weeks 13 and 15, the ventricular zone undergoes changes, leading to the arrival of neurons destined for the middle layers of the cortex. By gestational week 18, the radial organization of the neocortex becomes clearly distinguishable, with the six distinct layers taking shape. This process involves the radial expansion of the cortical plate and subplate, marking a critical milestone in the structural development of the cerebral cortex.


2.  Distinct Cortical Layers: The six-layered structure of the cortex consists of layers with unique cellular compositions and functions. Each layer contains specific types of neurons that contribute to information processing and neural circuitry within the brain. The formation of these layers is essential for establishing the functional organization of the cerebral cortex and enabling complex cognitive processes.


3. Neuronal Maturation: As the cortex forms its six-layered structure, cortical neurons undergo maturation processes that are crucial for their functional integration into neural circuits. Neurons in different layers exhibit varying degrees of maturity, with older neurons in deeper layers forming connections earlier than younger neurons in superficial layers. This maturation process is essential for the establishment of functional connectivity within the developing cortex.


4. Developmental Gradients: During cortical layer formation, developmental gradients are observed in terms of neuronal age and morphology. Young cortical neurons in deep layers exhibit elongated cell bodies and descending axons, while older neurons in superficial layers have rounded cell bodies and elongated dendrites perpendicular to the cortical surface. These gradients reflect the temporal sequence of neuronal generation and migration, contributing to the establishment of the laminar organization of the cortex.


5.  Absence of Horizontal Connections: By gestational week 18, while the six-layered cortex is taking shape, horizontal intracortical connections have not yet developed. The focus during this period is on the radial expansion of the cortical plate and the establishment of the vertical organization of the cortical layers. The absence of horizontal connections highlights the early stages of cortical development and the ongoing processes shaping the structural framework of the cortex.


In summary, gestational week 18 represents a critical juncture in brain development when the cortex completes the formation of its six-layered structure. The establishment of distinct cortical layers, the maturation of cortical neurons, and the presence of developmental gradients contribute to the functional specialization and connectivity of the developing cerebral cortex. Understanding the events that occur until gestational week 18 is essential for unraveling the complexities of cortical development and the emergence of the mature brain's structural and functional organization.

 

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