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Unveiling Hidden Neural Codes: SIMPL – A Scalable and Fast Approach for Optimizing Latent Variables and Tuning Curves in Neural Population Data

Dr. Rishabh Pathak
This research paper presents SIMPL (Scalable Iterative Maximization of Population-coded Latents), a novel, computationally efficient algorithm designed to refine the estimation of latent variables and tuning curves from neural population activity. Latent variables in neural data represent essential low-dimensional quantities encoding behavioral or cognitive states, which neuroscientists seek to identify to understand brain computations better. Background and Motivation Traditional approaches commonly assume the observed behavioral variable as the latent neural code. However, this assumption can lead to inaccuracies because neural activity sometimes encodes internal cognitive states differing subtly from observable behavior (e.g., anticipation, mental simulation). Existing latent variable models face challenges such as high computational cost, poor scalability to large datasets, limited expressiveness of tuning models, or difficulties interpreting complex neural network-based functio...
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Different Types of Sample Designs

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Dr. Rishabh Pathak

There are different types of sample designs that researchers can employ based on various factors such as the representation basis and the element selection technique. Here are the main categories of sample designs:


1.    Probability Sampling:

§  Probability sampling involves random selection of elements from the population, where each element has a known and non-zero chance of being included in the sample. Common types of probability sampling include:

§  Simple Random Sampling: Every member of the population has an equal chance of being selected.

§ Stratified Sampling: The population is divided into homogeneous subgroups (strata), and samples are randomly selected from each stratum.

§  Cluster Sampling: The population is divided into clusters, and a random sample of clusters is selected for inclusion.

§ Systematic Sampling: Elements are selected at regular intervals from a list or sequence.

2.    Non-Probability Sampling:

§  Non-probability sampling does not involve random selection of elements, and the likelihood of any element being included in the sample is unknown. Some common types of non-probability sampling include:

§  Convenience Sampling: Elements are selected based on their availability and accessibility.

§  Purposive Sampling: Researchers deliberately choose specific elements based on predefined criteria.

§ Snowball Sampling: Existing participants recruit new participants to form the sample.

§  Quota Sampling: Researchers select participants based on pre-defined quotas to ensure representation.

3.    Unrestricted and Restricted Sampling:

§  Based on the element selection technique, samples can be classified as unrestricted or restricted:

§  Unrestricted Sampling: Each sample element is drawn individually from the population at large, without any restrictions.

§  Restricted Sampling: In restricted sampling, there are limitations or conditions imposed on the selection of sample elements.

4.    Mixed Sampling Methods:

§  Researchers may also use a combination of different sampling methods to enhance the representativeness and efficiency of the sample design. For example, a study may employ a combination of stratified sampling and cluster sampling to achieve a more comprehensive sample representation.

5.    Complex Sampling Designs:

§  In some research studies, complex sampling designs may be necessary to address specific research questions or population characteristics. These designs may involve multiple stages of sampling, stratification, weighting, and clustering to ensure the validity and reliability of the results.

By selecting an appropriate sample design that aligns with the research objectives, population characteristics, and data collection methods, researchers can enhance the quality and generalizability of their findings. Understanding the different types of sample designs and their implications can help researchers make informed decisions when designing and implementing sampling strategies in research studies.

 

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